Stina Oredsson, professor

I was born 1954 in New Orleans, Louisiana, USA. My father worked at Svenska Tändsticksbolaget AB (Swedish match factory) in the good years when they only made matches. By way of Burma where my father also worked a few years at a Swedish match factory I ended up in the city of Jönköping where my great interest for biology started.

When I came to Lund in 1976, I only wanted to study biology with no specific goal. I was just fascinated by cells and here I still am working with fascinating questions of cell biology. More specifically I am now concentrating on understanding the difference between normal cells and cancer cells and how cancer cells can selectively be killed in cancer treatment. As experimental systems we use human cell lines derived from normal tissue and from different kinds of cancers such as breast, prostate, pancreas and neuroblastoma. We treat the cell lines with new potential chemotherapeutic drugs and investigate effects on e.g. cell proliferation, cell death, cancer stem cells and then relate sensitivity to the molecular level investigating proteins in signal transduction pathways. Cooperation with researchers at chemical, physical and medical departments is very important for my research where we are testing new compounds for cancer treatment. I am involved in teaching concerning the use of cells in culture in biological and toxicological contexts. I was appointed Docent at Lund University in 1989, and Professor of Zoophysiology in 2000.

I am married to Sven and we have four children (Jakob, born 1985; Hanna, born 1987; Joel, born 1990, Simon, born 1997). To get energy for the demanding academic work, I run, cross country ski and bike. Singing in a choire is important for relaxation.

PhD students

Helena Cirenajwis

Tânia Magalhães

Selected publications

Cirenajwis, H, Smiljanic, S, Honeth, G, Hegardt, C, Marton, LJ, and Oredsson, SM Reduction of the putative CD44+CD24- breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047. Anti-Cancer Drugs 21:897-906, 2010.

Söderstjerna, E, Holst, CM, Alm, K, and Oredsson, SM Apoptosis induced by the potential chemotherapeutic drug N1,N11-diethylnorspermine in a neuroblastoma cell line. Anti-Cancer Drugs21:917-926, 2010.

Freiburghaus, C, Welinder, C, Tjörnstad, U, Lindmark-Månsson, H, Paulsson, M, and Oredsson, S Identification of ubiquitin in bovine milk and its growth inhibitory effects on human cancer cell lines. J Dairy Sci 93:3442-3452, 2010.

Alm, K, and Oredsson, S Cells and polyamines do it cyclically. Essays Biochem 46:63-76, 2009.

Freiburghaus, C, Janicke, B, Lindmark-Månsson, H, Oredsson, SM, and Paulsson, MA Lactoferricin treatment decreases the rate of cell proliferation of a human colon cancer cell line. J Dairy Sci 92:2477-84, 2009.

Myhre, L, Alm, K, Johansson, M, and Oredsson, SM Normal-like breast cells, but not breast cancer cells, recovered from treatment with N1,N11-diethylnorspermine. Anti-Cancer Drugs20:230-237, 2009.

Holst, CM, Nevsten, P, Johansson, F, Carlemalm, E, and Oredsson, SM Subcellular distribution of spermidine/spermine N1-acetyltransferase.Cell Biol Int 32:39-47, 2008.

Holst, CM, Johansson, VM, Alm, K, and Oredsson, SM Novel anti-apoptotic effect of Bcl-2: prevention of polyamine depletion-induced cell death. Cell Biol Int 32:66-74, 2008.

Larsson, S, Rydén, T, Johansson, M, Oredsson, SM, and Holst, U Estimating the total rate of DNA replication using branching process.Math Biol 70:2177-2194, 2008.

Johansson, VM, Miniotis, MF, Hegardt, C, Jönsson, G, Staaf, J, Berntsson, PSH, Oredsson, SM, and Alm, K Effect of polyamine deficiency on proteins involved in Okazaki fragment maturation. Cell Biol Int 32: 1467-1477, 2008.

Holst, CM, Staaf, J, Jönsson, G, Hegardt, C and Oredsson, SM Molecular mechanisms behind N1,N11-diethylnorspermine-induced apoptosis in a human breast cancer cell line. Anti-Cancer Drugs19: 871-883, 2008.

Johansson, VM, Oredsson, SM, and Alm, K Polyamine depletion with two different polyamine analogues causes DNA damage in human breast cancer cell lines. DNA Cell Biol27:511-516, 2008.

Larsson, S, Rydén, T, Holst, U, Oredsson, SM, and Johansson, M Estimating the variation in S phase duration from flow cytometric histograms. Math Biosci 213:40-49, 2008.

Holst, CM, Nevsten, P, Johansson, F, Carlemalm, E, and Oredsson, SM Subcellular distribution of spermidine/spermine N1-acetyltransferase.Cell Biol Int 32:39-47, 2008.

Holst, CM, Johansson, VM, Alm, K, and Oredsson, SM Novel antiapoptotic effects of Bcl-2: Prevention of polyamine depletion-induced cell death. Cell Biol Int 32:66-74, 2008.

Myhre, L, Alm, K, Hegardt, C, Staff, J, Jönsson, G, Larsson, S, andOredsson, SM Different cell cycle kinetic effects of N1,N11-diethylnorspermine-induced polyamine depletion in four human breast cancer cell line.Anti-Cancer Drugs 19:359-368, 2008.

Larsson, S, Rydén, T, Holst, U, Oredsson, S, and Johansson, M Estimating the distribution of G2 phase duration from flow cytometric histograms Math Biosci 211:1-17, 2008.

Oredsson, SM, Alm, K, Dahlberg, E, Holst, CM,Johansson, VM, Myhre, L, and Söderstjerna, E Inhibition of cell proliferation and induction of apoptosis by N1,N11-diethylnorspermine-induced polyamine pool reduction.Biochem Soc Transact 35:405-409, 2007.

Ghatnekar, J, Hägerlöf, M, Oredsson S, Alm, K, Elmroth, SK, and Persson, T Construction of polyamine-modified uridine and adenosine derivatives - evaluation of DNA binding capacity and cytotoxicity in vitro.Bioorg Med Chem 15:7426-7433, 2007.

Jönsson, G, Staaf, J, Olsson, E, Heidenblad, M, Vallon-Christersson, J, Osoegawa, K, de Jong, P, Oredsson, S, Ringnér, M, Höglund, M, andBorg, Å High-resolution genomic profiles of breast cancer cell lines assessed by tiling BAC array comparative genomic hybridization.Genes Chrom Cancer 46:543-558, 2007.

Holst, M, Frydman, B, Marton, L, and Oredsson, SM Cytotoxic effects of novel polyamine analogues on human breast cancer cell lines. Toxicology 223:71-78, 2006.

Olsson, ME, Andersson, CS, Oredsson, SM, Berglund, RH, andGustavsson, K-E Antioxidant levels and inhibition of cancer cell proliferation in vitro by extracts from organically and conventionally cultivated strawberries.J Agric Food Chem 54:1248-1255, 2006.

Janicke, B, Önning, G, and Oredsson, SM Differential effects of ferulic acid and p-coumaric acid on S phase distribution and length of S phase in the human colonic cell line Caco-2.J Agric Food Chem 53:6658-6665, 2005.

Nasizadeh, S, Myhre, L, Thiman, L, Alm, K, Oredsson, SM, andPersson, L Importance of polyamines in cell cycle kinetics as studied in a transgenic system. Exp Cell Res 308:254-264, 2005.

Larsson, S Johansson, M, Oredsson, SM, and Holst, U A Markov model approach shows a large variation in the length of the S phase in MCF-7 breast cancer cells. Cytometry A 65:15-25, 2005.

Holst, M and Oredsson, SM Comparison of three cytotoxicity tests in the evaluation of the cytotoxicity of a spermine analogue on human breast cancer cell lines.Tox In Vitro 19:379-387, 2005.

Hegardt, C, Andersson, G, and Oredsson, SM Spermine prevents cytochrome c release in glucocorticoid-induced apoptosis in mouse thymocytes. Cell Biol Int 27:115-121, 2003.

Johannsson, OT, Staff, S, Vallon-Christersson J, Kytola, S, Gudjonsson, T, Rennstam, K, Hedenfalk, IA, Adeyinka, A, Kjellen, E, Wennerberg, J, Baldetorp, B, Petersen, OW, Olsson, H, Oredsson, S, Isola, J, andBorg, A Characterization of a novel breast carcinoma xenograft and cell line derived from a BRCA1 germ-line mutation carrier.Lab Invest 83:387-396, 2003.

Hegardt, C, Johansson, O, and Oredsson, SM Rapid caspase-dependent cell death in a human breast cancer cells induced by the polyamine analogue N1,N11-diethylnorspermine.Eur J Biochem 269:1033-1039, 2002.

Hegardt, C, Andersson, G, and Oredsson, SM Different roles of spermine in gluucocorticoid- and Fas-induced apoptosis. Exp Cell Res 266:333-341, 2001.

Alm, K, Berntsson, PSH, Kramer, D, Porter, CW, and Oredsson, SM Treatment of cells with the polyamine analogN1,N11-diethylnorspermine retards S phase progression within one cell cycle. Eur J Biochem 267:4157-4164, 2000.

Nilsson, C, Andersson, G, and Oredsson, SM Changes in polyamine metabolism during glucocorticoid-induced programmed cell death in mouse thymus.Cell Biol Internat 24:871-880, 2000.

Alm, K and Oredsson, SM The organization of replicon clusters is not affected by polyamine depletion. J Struct Biol 131:1-9, 2000.

Berntsson, P, Alm, K, and Oredsson, SM Half lives of ornithine decarboxylase and S-adenosylmethionine decarboxylase during the cell cycle.Biochem Biophys Res Commun 263:13-16, 1999.

Alm, K, Berntsson, P, and Oredsson, SM Topoisomerase II is non-functional in polyamine-depleted cells.J Cell Biochem 75:46-55, 1999.

Johansson, MC, Johansson, R, Baldetorp, B, and Oredsson, SM Comparison of different labelling index formulas used on bromodeoxyuridine - flow cytometry data.Cytometry 32:233-240, 1998.

Hedenfalk, IA, Baldetorp, B, Borg, Å, and Oredsson, SM Activated cell cycle checkpoints in epirubicin-treated breast cancer cells studied by BrdUrd - flow cytometry. Cytometry 29:321-327, 1997.

Fredlund, J and Oredsson, SM Ordered cell cycle phase perturbations in Chinese hamster ovary cells treated with an S-adenosylmethionine decarboxylase inhibitor.Eur J Biochem 249:232-238, 1997.

Johansson, MC, Baldetorp, B, and Oredsson, SM Comparison of mathematical formulas for estimation of DNA synthesis time of bromodeoxyuridine - labelled cell populations with different proliferative characteristics. Cell Prolif 29:525-538, 1996.

Fredlund, JO and Oredsson, SM Normal G1/S transition and prolonged S phase within one cell cycle after seeding of cells in the presence of a polyamine biosynthesis inhibitor. Cell Prolif 29:457-465, 1996.

Fredlund, JO and Oredsson, SM Impairment of DNA replication within one cell cycle in cells seeded in the presence of a polyamine biosynthesis inhibitor.Eur J Biochem 237:539-544, 1996.

Fredlund, J, Johansson, MC, Dahlberg, E, and Oredsson, SM Ornithine decarboxylase and S-adenosylmethionine decarboxylase expression during the cell cycle of Chinese hamster ovary cells.Exp Cell Res 216:86-92, 1995.

Johansson, MC, Baldetorp, B, Bendahl, PO, Johansson, R,and Oredsson, SM An improved mathematical method to estimate DNA synthesis time of bromodeoxy-uridine-labelled cells, using FCM-derived data.Cell Prolif 27:475-488, 1994.

Fredlund, JO, Johansson, M, Baldetorp, B, and Oredsson, SM Abnormal DNA synthesis in polyamine deficient cells revealed by bromodeoxyuridine - flow cytometry technique.Cell Prolif 27:243-256, 1994.


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Last modified 27 Nov 2012

Stina Oredsson
Contact information

Stina Oredsson
Professor
Functional zoology

Phone:
+46462229497

E-mail:
stina.oredsson@biol.lu.se

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Lund University, Box 117, SE-221 00 Lund, Sweden. Tel: +46 (0)46 222 00 00