We work within the fields of genetics, biochemistry, evolutionary biology, and molecular biology. Our focus is on these two research areas:
The image to the left in the header displays the structure of ultra-fast Drosophila deoxyribonucleoside kinase. This dimeric enzyme can phosphorylate a wide range of substrates and has been isolated and characterized in our laboratory. Recently it has been given its own IUPAC name, EC 188.8.131.52. It has a number of interesting properties which are now applied in the enzymatic synthesis of several compounds and in anti-cancer gene-therapy, using the kinase gene as a suicide gene. - The image to the right in the header depicts a monomer of the Drosophila multisubstrate kinase. - The photo to the left shows yeast cells belonging to the Brettanomyces/Dekkera group. These yeasts play a role in wine maturation but are also very interesting as model organisms helping us to understand yeast genomics and the molecular mechanisms which have operated during yeast evolution.