I did a master in Molecular Biology at Lund University, into which I included a one year biomedical research school at Linköping University. During this time I was involved in three projects; my master about pyrimidine metabolism in Saccharomyces kluyveri in Lund, and in Linköping I did screening of rat tumors for Notch1 mutations (published) and also looked at duplication of the c-Myc gene in human breast tumors using q-PCR. Since 2008 I'm a PhD student in Jure Piskurs group.
I'm amased by how very small genetic changes or differences can have such a great impact on the organisms health, appearance and fitness.
My PhD is focused on pyrimidine degradation in yeast, which occurs in an entierly different way than in fx. mammals, insects and plants. Pyrimidines are building blocks for nucleic acids, and the degradation is an important part of the regulation of their intracellular pools. The Baker's yeast Saccharomyces cerevisiae doesn't have a pathway for pyrimidine degradation, so instead study its distant relative, Through studies of the yeast Saccharomyces (Lachancea) kluyveri we have found a novel degradation pathway called URC, which is the second found in eukaryots. I'm investigating the function of the involved genes and trying to determine how they are regulated.
I am a lab assistant in Molecular methothds course, and will now also teach in the basic microbiologi and genetics course. I also sometimes hold lectures related to my work.
When I don't work I like to spend time with my fiancé and my cats, and to go mushroom hunting with my family.
O. Björnberg, M. Vodnala, V. Domkin, A. Hofer, A. Rasmussen, G. Andersen & J. Piškur 2010. Ribosylurea Accumulates in Yeast urc4 Mutants. Nucleosides, Nucleotides and Nucleic Acids Volume 29, Issue 4-6.
Anneli Karlsson, Jonas Ungerbäck, Anna Rasmussen, John E. French, Peter Söderkvist. 2008. Notch1 is a frequent mutational target in chemically induced lymphoma in mouse. International Journal of Cancer Volume 123, Issue 11, pages 2720–2724.
Gorm Andersen, Olof Björnberg, Silvia Polakova, Yuriy Pynyaha, Anna Rasmussen, Kasper Møller, Anders Hofer, Thomas Moritz, Michael Paolo Bastner Sandrini, Anna-Maria Merico, Concetta Compagno, Hans-Erik Åkerlund, Zoran Gojković, Jure Piškur. 2008. A Second Pathway to Degrade Pyrimidine Nucleic Acid Precursors in Eukaryotes. Journal of Molecular Biology Volume 380, Issue 4, Pages 656-666